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Paradoxical Reaction to Midazolam Used in Intravenous Sedation for Dental Treatment -Report of a Case and Review of the Literature-

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ÀüÀçÀ± ( Jeon Jae-Yun ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú
Á¤¼¼È­ ( Jung Se-Hwa ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú
À̺´ÇÏ ( Lee Byung-Ha ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú
ÀÓÀçÁß ( Im Jae-Jung ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç Ä¡°ú±³Á¤°ú
Ȳ°æ±Õ ( Hwang Kyung-Gyun ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú
½É±¤¼· ( Shim Kwang-Sub ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú
¹ÚâÁÖ ( Park Chang-Joo ) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ Ä¡°úÇб³½Ç ±¸°­¾Ç¾È¸é¿Ü°ú

Abstract


Midazolam, one of the most common benzodiazepine derivatives, is widely used in intravenous sedation for dental treatment without severe complications. However, paradoxical reactions to midazolam, including patient¡¯s unanticipated restlessness, agitation, hostility, and rage, have been frequently reported since the introduction of benzodiazepine. During outpatient intravenous sedation using midazolam for dental treatment, we experienced a paradoxical reaction to midazolam in a 28-year-old female patient. With a thorough review of the literature, the management of this complication and its various etiologies were discussed.

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Behavior and behavioral mechanisms; Benzodiazepine; Flumazenil; Midazolam

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